There are a lot of interesting blogs out there from successful and promising indie developers. Ron Carmel of 2D Boy had some interesting things to say in this
blog.
They took some personal and financial gambles with that project, much more than I think I'm ready to take at this time. It might be their industry experience that gave them the confidence to take those leaps of faith. Winning in several categories at the IGF certainly didn't hurt their chances, although that must have been late in development. It shows that to make it, you may have to persevere well past the point where many would give up.